Molecular genetic evolution analysis of new A(H1N1) influenza virus / 病毒学报
Chinese Journal of Virology
;
(6): 88-96, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-297901
ABSTRACT
In order to analyze the molecular epidemiology of A (H1N1) influenza virus in 2009, the complete genome sequences of influenza strains from different host sources downloaded from the NCBI were analyzed on genetic evolution by DNAstar software in this research. The results showed that 79 mutation sites of new A (H1N1) influenza virus were observed compared to previous human A (H1N1) influenza strain, including 14 mutation sites new in all A (H1N1) influenza sources and 37 mutation sites only observed in swine strain. A significant difference was represented in antigenic sites between new A (H1N1) influenza strain and the previous human A (H1N1) strain. This phenomenon shows the new A (H1N1) influenza strain is either originated from the recombination of human and swine strain or from the infection in pig populations and gradual mutation to human tansmission, which remains to be further studied.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Filogenia
/
Suínos
/
Doenças dos Suínos
/
Virologia
/
Aves
/
Classificação
/
Infecções por Orthomyxoviridae
/
Evolução Molecular
/
Glicoproteínas de Hemaglutininação de Vírus da Influenza
/
Bases de Dados de Ácidos Nucleicos
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Virology
Ano de publicação:
2010
Tipo de documento:
Artigo
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