Biological characteristics of a chimeric rabies virus expressing canine parvovirus VP2 protein / 病毒学报
Chinese Journal of Virology
;
(6): 362-367, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-297947
ABSTRACT
To obtain a bivalence vaccine against canine rabies virus and canine parvovirus, a chimeric rabies virus expressing canine parvovirus VP2 protein was generated by the technique of reverse genetics. It was shown that the chimeric virus designated as HEP-Flury (VP2) grew well on BHK-21 cells and the VP2 gene could still be stably expressed after ten passages on BHK-21 cells. Experiments on the mice immunized with the chimeric virus HEP-Flury (VP2) demonstrated that specific antibodies against rabies virus and canine parvovirus were induced in immunized mice after vaccination with the live chimeric virus.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Raiva
/
Vírus da Raiva
/
Virologia
/
Vacinas Virais
/
Linhagem Celular
/
Parvovirus Canino
/
Reação em Cadeia da Polimerase Via Transcriptase Reversa
/
Proteínas do Capsídeo
/
Alergia e Imunologia
/
Genética
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Virology
Ano de publicação:
2009
Tipo de documento:
Artigo
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