Lead compound optimization strategy (2)--structure optimization strategy for reducing toxicity risks in drug design / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1-15, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-297978
ABSTRACT
Idiosyncratic adverse drug reactions (IDR) induce severe medical complications or even death in patients. Alert structure in drugs can be metabolized as reactive metabolite (RM) in the bodies, which is one of the major factors to induce IDR. Structure modification and avoidance of alert structure in the drug candidates is an efficient method for reducing toxicity risks in drug design. This review briefly summarized the recent development of the methodologies for structure optimization strategy to reduce the toxicity risks of drug candidates. These methods include blocking metabolic site, altering metabolic pathway, reducing activity, bioisosterism, and prodrug.
Texto completo:
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Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Relação Estrutura-Atividade
/
Sítios de Ligação
/
Desenho de Fármacos
/
Sistema Enzimático do Citocromo P-450
/
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
/
Recall de Medicamento
/
Descoberta de Drogas
/
Metabolismo
/
Métodos
Tipo de estudo:
Estudo de etiologia
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2014
Tipo de documento:
Artigo
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