Repeated injection of mitoxantrone containing thermosensitive liposomes in rat induced ABC phenomenon / 药学学报
Acta Pharmaceutica Sinica
;
(12): 256-259, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-297983
ABSTRACT
To investigate whether accelerated blood clearance (ABC) phenomenon could be induced after repeated injection of mitoxantrone thermosensitive liposomes, LC-MS/MS and enzyme linked immunosorbent assay (ELISA) were used to measure the concentration of mitoxantrone and the anti-polyethylene glycol (PEG) IgM levels in rat plasma, separately. The drug was rapidly cleared away after the second administration. The anti-PEG IgM was detected after the first dose which was neutralized quickly after the second dose. It is proved that repeated administration of mitoxantrone thermosensitive liposomes in rat caused the ABC phenomenon.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polietilenoglicóis
/
Sangue
/
Imunoglobulina M
/
Farmacocinética
/
Taxa de Depuração Metabólica
/
Química
/
Cromatografia Líquida de Alta Pressão
/
Mitoxantrona
/
Ratos Wistar
/
Espectrometria de Massas por Ionização por Electrospray
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2014
Tipo de documento:
Artigo
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