Progress in the study of core-crosslinked polymeric micelles in drug delivery system / 药学学报
Acta Pharmaceutica Sinica
;
(12): 183-189, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-297995
ABSTRACT
The core-crosslinked polymeric micelles were used as a new drug delivery system, which can decrease the premature drug release in blood circulation, improve the stability of the micelles, and effectively transport the drug into the therapy sites. Then the drug bioavailability increased further, while the side effect reduced. Most drugs were physically entrapped or chemically covalent with the polymer in the internals of micelles. Based on the various constitutions and properties of polymeric micelles as well as the special characteristics of body microenvironment, the environment-responsive or active targeting core-crosslinked micelles were designed and prepared. As a result, the drug controlled release behavior was obtained. In the present paper, the research progress of all kinds of core-crosslinked micelles which were published in recent years is introduced. Moreover, the characteristic and application prospect of these micelles in drug delivery system are analyzed and summarized.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tamanho da Partícula
/
Polietilenoglicóis
/
Polímeros
/
Portadores de Fármacos
/
Preparações Farmacêuticas
/
Estrutura Molecular
/
Química
/
Reagentes de Ligações Cruzadas
/
Usos Terapêuticos
/
Tratamento Farmacológico
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2014
Tipo de documento:
Artigo
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