Synthesis and structure-activity relationship of cycloberberine as anti-cancer agent / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1800-1806, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-298008
ABSTRACT
A series of cycloberberine derivatives were designed, synthesized and evaluated for their anti-cancer activities in vitro. Among these analogs, compounds 6c, 6e and 6g showed strong inhibition on human HepG2 cells. They afforded a potent effect against DOX-resistant MCF-7 breast cells as well. The primary mechanism showed that cell cycle was blocked at G2/M phase of HepG2 cells treated with 6g using flow cytometry assay. It significantly inhibited the activity of DNA Top I at the concentration of 0.1 mg mL-1. Our results provided a basis for the development of this kind of compounds as novel anti-cancer agents.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Relação Estrutura-Atividade
/
Berberina
/
Estrutura Molecular
/
Doxorrubicina
/
Ciclo Celular
/
Química
/
DNA Topoisomerases Tipo I
/
Resistencia a Medicamentos Antineoplásicos
/
Proliferação de Células
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2013
Tipo de documento:
Artigo
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