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Analysis and comparison of intestinal absorption of components of Gegenqinlian decoction in different combinations based on pharmacokinetic parameters / 药学学报
Acta Pharmaceutica Sinica ; (12): 1611-1617, 2013.
Artigo em Chinês | WPRIM | ID: wpr-298036
ABSTRACT
To analyse and compare the characteristics of the intestinal absorption of puerarin, baicalin, berberine and liquiritin in different combinations of Gegenqinlian decoction based on pharmacokinetic parameters, a sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was applied for the quantification of four components in rat's plasma. And pharmacokinetic parameters were determined from the plasma concentration-time data with the DAS software package. The influence of different combinations on pharmacokinetics of four components was studied to analyse and compare the absorption difference of four components, together with the results of the in vitro everted gut model and the rat single pass intestinal perfusion model. The results showed that compared with other combinations, the AUC values of puerarin, baicalin and berberine were increased significantly in Gegenqinlian decoction group, while the AUC value of liquiritin was reduced. Moreover, the absorption of four components was increased significantly supported by the results from the in vitro everted gut model and the rat single pass intestinal perfusion model, which indicated that the Gegenqinlian decoction may promote the absorption of four components and accelerate the metabolism of liquiritin by the cytochrome P450.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Plantas Medicinais / Berberina / Flavonoides / Sangue / Medicamentos de Ervas Chinesas / Farmacocinética / Distribuição Aleatória / Química / Cromatografia Líquida de Alta Pressão / Ratos Sprague-Dawley Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Chinês Revista: Acta Pharmaceutica Sinica Ano de publicação: 2013 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Plantas Medicinais / Berberina / Flavonoides / Sangue / Medicamentos de Ervas Chinesas / Farmacocinética / Distribuição Aleatória / Química / Cromatografia Líquida de Alta Pressão / Ratos Sprague-Dawley Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Chinês Revista: Acta Pharmaceutica Sinica Ano de publicação: 2013 Tipo de documento: Artigo