Advances in the research of anti-CD20 therapeutic monoclonal antibodies / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1515-1520, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-298049
ABSTRACT
As targeted drugs to B-cell malignancies, anti-CD20 monoclonal antibodies have been proved to be important in therapeutic antibody field. With three generations in more than ten years' development, the structures of these drugs have been improved, and many new indications have been found. Nowadays, these kinds of antibodies are not only used in the treatment of lymphoid malignancies, but also been proved to be useful in some autoimmune diseases treatment, and their new indications are still being expanded. With the optimization of their clinical dosage regimens, drug reaction has been increased, thus, therapeutic and side effects of anti-CD20 monoclonal antibody have been further improved as well. However, the exact mechanism of action of their combination therapy with other chemical drugs is still unclear, which remains to be further studied. This article reviewed new development of anti-CD20 therapeutic monoclonal antibodies research in recent years.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Artrite Reumatoide
/
Linfoma não Hodgkin
/
Leucemia Linfocítica Crônica de Células B
/
Antígenos CD20
/
Usos Terapêuticos
/
Tratamento Farmacológico
/
Alergia e Imunologia
/
Anticorpos Monoclonais Humanizados
/
Rituximab
/
Anticorpos Monoclonais
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2013
Tipo de documento:
Artigo
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