Preparation of nanopaticles of SCF-CO2 extraction of Magnolia officinalis / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 390-393, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-298395
ABSTRACT
<p><b>OBJECTIVE</b>To prepare nano-particles of SCF-CO2 extraction of Magnolia officinalis with rapid expansion of supercritical solution (RESS) and optimize the preparation procedure with orthogonal experiment.</p><p><b>METHOD</b>The preparation procedures were optimized by orthogonal test L9(3(4)) with the mean particle size and the amounts of total-phenol as indexes. Factors of the extraction pressure and temperature, diameter of nozzle, pre-expansion temperature were evaluated for their effects on preparation process.</p><p><b>RESULT</b>The optimal preparation technology was as follows the pressure was at 25 MPa and temperature was at 50 degrees C, the diameter of nozzle was 200 microm, the pre-expansion temperature was at 30 degrees C. The nano-particles solution was settled, of which the average particle size was 303.50 nm and the total-phenol contents was 0.091 g x L(-1), and the stability of the particle size kept well after 1 month of storage at low temperature and obturation the mean particle size.</p><p><b>CONCLUSION</b>The RESS method is applicable for preparing nanoparticles solution of SCF-CO2 extraction of M. officinalis at low operating temperature. It is simple processing, and no environmental pollution, and no residual solvent.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tamanho da Partícula
/
Solubilidade
/
Temperatura
/
Dióxido de Carbono
/
Extratos Vegetais
/
Química
/
Tecnologia Farmacêutica
/
Cromatografia com Fluido Supercrítico
/
Magnolia
/
Nanopartículas
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2009
Tipo de documento:
Artigo
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