Effect of Acorus tatarinowii schott on ultrastructure and permeability of blood-brain barrier / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To explore the influence of Acorus tatarinowii schott on ultrastructure and permeability of BBB.</p><p><b>METHOD</b>The ultrastructure and permeability of BBB on rats with A. tatarinowii by electron microscope were observed. The even's blue (EB) and sodium phenytoin in brain was determined by UV and HPLC-MS.</p><p><b>RESULT</b>After give A. tatarinowii, tight junctions of the endothelial cell opened in cotex, and the concentration of EB and sodium phenytoin in brain are significant increased.</p><p><b>CONCLUSION</b>A. tatarinowii can increase the permeability of BBB, and show its 'Kaiqiao' effect.</p>