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Preparation and release characterization in vitro of pulsed-release tablets of compound Danshen / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 30-34, 2009.
Artigo em Chinês | WPRIM | ID: wpr-298471
ABSTRACT
<p><b>OBJECTIVE</b>To prepare pulsed-release tablet (PTS) according to the rhythm of coronary heart disease based on efficacy material and the mechanism of compound Danshen.</p><p><b>METHOD</b>PTS were achieved by coating the core which contains drugs, CMS-Na, lactose, succinic acid and MCC with separation layer (Eudragit RL), swelling layer (HPMC E5), and controlled-release membrane (Eudragit RS-RL-EC).</p><p><b>RESULT</b>The results of in vitro experiments showed that no difference was observed among the profiles of Danshensu, protocatechuic aldehyde, ginsenoside Rg1, Rb1, notoginsenoside R1 release from the two-step release system. And it indicated that swelling was the basis and prerequisite for drug release from PTS, and the diffusion, organic acid-induced, and osmotic pumping mechanism were involved in drug release, but the latter they were the dominant factors.</p><p><b>CONCLUSION</b>Successfully obtained the PTS of a certain lag-time behind the rapid release which indicate that after bed time administration of such device, the drug plasma concentration-time curve CAN meet the requirements of chronotherapy of cardiovascular disease.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Osmose / Comprimidos / Fatores de Tempo / Benzaldeídos / Medicamentos de Ervas Chinesas / Catecóis / Química / Cromatografia Líquida de Alta Pressão / Sistemas de Liberação de Medicamentos / Doença das Coronárias Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2009 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Osmose / Comprimidos / Fatores de Tempo / Benzaldeídos / Medicamentos de Ervas Chinesas / Catecóis / Química / Cromatografia Líquida de Alta Pressão / Sistemas de Liberação de Medicamentos / Doença das Coronárias Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2009 Tipo de documento: Artigo