The expression of human macrophage metalloelastase mRNA in gastric cancer cell lines and tissues and its clinical significance / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 830-832, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-298501
ABSTRACT
<p><b>OBJECTIVE</b>To make measurement of the expression of HME mRNA in both gastric cancer cell lines and tissues and evaluate its role in development of gastric cancer.</p><p><b>METHODS</b>The HME mRNA expression in 3 gastric cancer cell lines and tissues was detected by real-time fluorescent quantitative PCR.</p><p><b>RESULTS</b>All three gastric cancer cell lines expressed HME mRNA, and the HME mRNA expression level in gastric cancer tissues was higher than that in normal tissues (P <0.05). The rate of lymph node metastasis of HME mRNA positive cases was lower than that of HME mRNA negative ones (P < 0.05). Expression of drug resistance gene GST of HME mRNA positive cases was lower than that of HME mRNA negative ones (P <0.05). The two-year survival rate of HME mRNA positive cases was higher than that of HME mRNA negative ones (P < 0.05). There was no correlation between the expression of HME gene and the tumor location, size, depth of invasion, degree of malignancy, expression of drug resistance gene top II and PG.</p><p><b>CONCLUSION</b>The expression of HME gene in gastric cancers may be related with lower possibility of metastasis and predict a better prognosis.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Neoplasias Gástricas
/
RNA Mensageiro
/
Taxa de Sobrevida
/
Seguimentos
/
Linhagem Celular Tumoral
/
Metaloproteinase 12 da Matriz
/
Mucosa Gástrica
/
Genética
/
Glutationa Transferase
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Oncology
Ano de publicação:
2007
Tipo de documento:
Artigo
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