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Clinical evaluation of efficacy and safety of nateglinide in the treatment of type 2 diabetes / 中国医学科学院学报
Acta Academiae Medicinae Sinicae ; (6): 211-213, 2008.
Artigo em Chinês | WPRIM | ID: wpr-298710
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and safety of nateglinide, a new antidiabetic agent, in the treatment of type 2 diabetes.</p><p><b>METHODS</b>A total of 219 treatment-naïve patients with type 2 diabetes from 6 centers were enrolled in this study and blindly divided into nateglinide group (n = 105) and repaglinide group (n = 114). In all patients, the disease was confirmed for at least three months. The whole observation lasted for 12 weeks. The efficacy indicators measured include glycohemoglobin A1c (HbA1c), fasting blood glucose, and 2 hours postprandial blood glucose, and the safety parameters measured included renal and hepatic function, serum lipids, and blood and urea profiles.</p><p><b>RESULTS</b>Similar decreases in fasting blood glucose, 2 hours postprandial blood glucose, and HbA1 c were found in both nateglinide group and repaglinide group without significant differences. No severe adverse events were noted. The hypoglycemia event reports were not significantly different between these two groups.</p><p><b>CONCLUSION</b>Nateglinide is an effective and safe drug in treating type 2 diabetes.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fenilalanina / Glicemia / Esquema de Medicação / Resultado do Tratamento / Cicloexanos / Usos Terapêuticos / Diabetes Mellitus Tipo 2 / Tratamento Farmacológico / Hipoglicemiantes Limite: Feminino / Humanos / Masculino Idioma: Chinês Revista: Acta Academiae Medicinae Sinicae Ano de publicação: 2008 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fenilalanina / Glicemia / Esquema de Medicação / Resultado do Tratamento / Cicloexanos / Usos Terapêuticos / Diabetes Mellitus Tipo 2 / Tratamento Farmacológico / Hipoglicemiantes Limite: Feminino / Humanos / Masculino Idioma: Chinês Revista: Acta Academiae Medicinae Sinicae Ano de publicação: 2008 Tipo de documento: Artigo