Current advances in the mechanic studies of human papillomavirus-induced oncogenesis / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 673-677, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-298760
ABSTRACT
Human papillomavirus (HPV) is a common small DNA tumor virus that specifically infects squamous epithelial cells and causes benign or malignant epithelial lesions such as genital warts and cervical cancer. High-risk HPV is detected in specimens of more than 90% of cervical cancer. In the 7. 9 kb genome of HPV, E6 and E7 are the crucial viral oncoproteins that consistently maintained after viral integration into host cell genome. These two proteins interfere with cell proliferation and differentiation through interacting with important tumor suppressors including p53 and pRb. High-risk HPV E6/E7 also induces genomic instability, facilitating cell transformation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Papillomaviridae
/
Patologia
/
Fisiologia
/
Virologia
/
Diferenciação Celular
/
Transformação Celular Neoplásica
/
Neoplasias do Colo do Útero
/
Proteínas Oncogênicas Virais
/
Infecções por Papillomavirus
/
Instabilidade Genômica
Limite:
Feminino
/
Humanos
Idioma:
Chinês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2007
Tipo de documento:
Artigo
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