Clinical evaluation of the xMAP technology in detection of high-risk human papillomavirus / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 603-607, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-298774
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the clinical application value of flexible multi-analyte profiling (xMAP) technology in detecting high-risk human papillomavirus (HR-HPV).</p><p><b>METHODS</b>Totally 1 061 women, aged 21-65 years, were randomly enrolled into the study. Cervical exfoliated cells were used in xMAP technology and hybrid capture II (hc2). Pathological diagnosis was used as golden standard. Consistency of these two methods was assessed.</p><p><b>RESULTS</b>The sensitivity and specificity of xMAP technology were 80.31% and 85.83%, respectively. The positive and negative predictive values were 44.5% and 96.9%, respectively. The Kappa value for consistency between xMAP technology and hc2 was 0.58.</p><p><b>CONCLUSIONS</b>The specificity of xMAP technology is similar to hc2 test, but the sensitivity is inferior to hc2. However, these two methods show good consistency in the detection of HR-HPV.</p>
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Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Papillomaviridae
/
Virologia
/
Doenças do Colo do Útero
/
Colo do Útero
/
Sensibilidade e Especificidade
/
Classificação
/
Infecções por Papillomavirus
/
Diagnóstico
/
Genética
/
Métodos
Tipo de estudo:
Estudo diagnóstico
/
Estudo de etiologia
/
Estudo prognóstico
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
Idioma:
Chinês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2007
Tipo de documento:
Artigo
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