The Effects of Nifedipine and Allopurinol on Shock Wave Induced Acute changes of Rabbit Ureter / 대한비뇨기과학회지
Korean Journal of Urology
;
: 16-22, 2001.
Artigo
em Coreano
| WPRIM
| ID: wpr-29912
ABSTRACT
PURPOSE:
Introduction of shock wave lithotripsy has provided an avenue for dealing with many urinary stones noninvasively. Although shock wave is known to cause pathologic changes in various organ, little is k nown about its effect on the ureter and recovery after shock wave, the target organ in SWL of injury induced by shock wave and the potential protective effect of allopurinol and nifedipine against shock wave. MATERIALS ANDMETHODS:
A total 24 rabbits were assigned to 2 groups. 12 rabbits received allopurinol(10mg.each) and nifedipine (1mg.each) that were given orally 3 times a day for 5 days starting the night before SWL. The other 12 rabbits reseived no medication. The left lower Ureter segments of 24 rabbits were removed ureter. Groups of 8 rabbits(4were medication group and 4, no medication group) were sacrificed 1, 3 and 5 days after shock wave exposure. The histomorphological alterations were examined under light and transmission electron microscopy.RESULTS:
The epithelial cells disclosed no change after shock wave application. Histologically the muscular layer was the most affected part of ureter. There was interstitial and intracellular edema on light microscopy and made chromatin and mitochondrial changes at the subcellular level. The adventitial layer wes also edematous. This chanfes were prominent on day 1and 3 and returned to normal on day 5. The medication group showed less severe features of injury, compared with the no medication group.CONCLUSIONS:
Electromagnetic shock waves produce reversible morphological changes in rabbit ureteric muscle and allopurinol and nifedipine may have its role in protecting the tissue injury produced by high energy shock waves.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Choque
/
Ureter
/
Litotripsia
/
Cromatina
/
Nifedipino
/
Cálculos Urinários
/
Alopurinol
/
Ondas de Choque de Alta Energia
/
Microscopia Eletrônica de Transmissão
/
Edema
Limite:
Animais
Idioma:
Coreano
Revista:
Korean Journal of Urology
Ano de publicação:
2001
Tipo de documento:
Artigo
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