Synthesis of novel curcumin mimics and preliminary evaluation for their antitumor activity / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1022-1028, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-299173
ABSTRACT
Curcumin has been reported to possess antitumor activity with low toxicity. However, the clinical application of curcumin has been significantly limited by its instability and poor metabolic property. In order to overcome these limitations and discover novel small molecules with potential antitumor activity, 29 curcumin mimics were synthesized, which were confirmed by 1H NMR and HR-MS, and their cytotoxic property was evaluated against five human cancer cell lines in vitro. Compounds 16, 18 and 19 exhibited good cytotoxic property, their IC50 value were even below 5 micromol x L(-1) to some cancer cell lines, 5-9 times better than curcumin.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Ensaios de Seleção de Medicamentos Antitumorais
/
Concentração Inibidora 50
/
Curcumina
/
Linhagem Celular Tumoral
/
Antineoplásicos
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2014
Tipo de documento:
Artigo
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