Atypical chronic myeloid leukaemia with trisomy 13: a case report / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal
;
(4): 254-256, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-299373
ABSTRACT
A typical chronic myeloid leukaemia (aCML), which shows both myeloproliferative and myelodysplastic features, is a type of myeloproliferative/myelodysplastic disease as defined by the World Health Organisation (WHO) classification of the myeloid neoplasms. Because of the presence of neutrophilic leukocytosis, aCML may resemble chronic myelogenous leukemia (CML). However, in contrast with CML, aCML does not have the Philadelphia chromosome or the bcr/abl fusion gene. With the continuous karotype analysis of aCML, several changes in the karyotype of aCML have been detected. However, few are recurring and no specific cytogenetic changes have been associated with aCML. Nonspecific cytogenetic abnormalities can be observed in 56%~82% of aCML cases. Although the most frequent abnormalities include trisomy 8 and del (20q), abnormalities involving other chromosomes such as 12, 13, 14, 17, and 19 have also been described. In this report we describe a case of aCML with trisomy 13.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Trissomia
/
Cromossomos Humanos Par 13
/
Leucemia Mieloide Crônica Atípica BCR-ABL Negativa
/
Genética
Limite:
Adulto
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Chinese Medical Sciences Journal
Ano de publicação:
2011
Tipo de documento:
Artigo
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