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Study on relations between transient receptor potential vanilloid 1 and pungent property of traditional Chinese medicines / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 2422-2427, 2014.
Artigo em Chinês | WPRIM | ID: wpr-299798
ABSTRACT
The five-flavor theory of traditional Chinese medicines (TCM) and the flavor efficacy generation mechanism has long been focuses and difficulties in studies on traditional Chinese medicinal properties. In this paper, by using the pharmacophore-based virtual screening technique, the authors discussed the relations between the pungent property and transient receptor potential vanilloid 1 (TRPV1) by studying the TCM components' role in regulating TRPV1 ion channel. The results showed that the matching relationship between TRPV1 agonist pharmacophore model and TCM chemical components could identify the active ingredients from pungent herbs. Therefore, the authors proposed that TRPV1 is one of the potential targets for efficient pungent herbs. The pungent property of TCMs is decided by its chemical components, and consistent with the inherited and additive characteristics.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Olfato / Paladar / Medicamentos de Ervas Chinesas / Química / Canais de Cátion TRPV / Metabolismo Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2014 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Olfato / Paladar / Medicamentos de Ervas Chinesas / Química / Canais de Cátion TRPV / Metabolismo Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2014 Tipo de documento: Artigo