Detection of serum levels of MMP-9 and VEGF in patients with bladder cancer / 中华外科杂志
Chinese Journal of Surgery
;
(12): 430-432, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-300015
ABSTRACT
<p><b>OBJECTIVE</b>To detect serum levels of MMP-9 and VEGF in patients with bladder cancer.</p><p><b>METHODS</b>Serum levels of MMP-9 and VEGF in 58 patients with bladder cancer and 45 healthy controls were measured by sandwich-ELISA.</p><p><b>RESULTS</b>Serum levels of MMP-9 and VEGF (737.12 micro g/L and 1148.88 ng/L) were significantly higher in the cancer patients than those of controls (423.51 micro g/L and 846.96 ng/L, P < 0.01). The serum levels were associated with tumor stage and grade. In patients with invasive cancer, the levels were significantly higher than those of superficial cancer (P < 0.01). Patients with distant metastasis had significantly higher levels of MMP-9 and VEGF than those with localized invasion (P < 0.01). But there was no significant difference between patients with superficial cancer and controls. Patients with G(3) tumors had significantly higher levels of MMP-9 and VEGF than those of patients with G(1) and G(2) tumors (P < 0.01).</p><p><b>CONCLUSIONS</b>Elevated MMP-9 and VEGF levels are associated with a high stage and grade of bladder cancer and they may serve as markers of tumor progression in the future.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Neoplasias da Bexiga Urinária
/
Sangue
/
Metaloproteinase 9 da Matriz
/
Fator A de Crescimento do Endotélio Vascular
/
Estadiamento de Neoplasias
Tipo de estudo:
Estudo diagnóstico
Limite:
Idoso
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Surgery
Ano de publicação:
2003
Tipo de documento:
Artigo
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