Local recurrence and distant metastasis after breast-conserving therapy for patients with breast cancer / 中华外科杂志
Chinese Journal of Surgery
; (12): 278-281, 2003.
Article
em Zh
| WPRIM
| ID: wpr-300067
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the relative factors of local recurrence and distant metastasis after breast-conserving therapy (BCT) for patients with breast cancer.</p><p><b>METHODS</b>The data on 174 patients with primary breast cancer who had been treated by BCT were analyzed retrospectively. The patients were followed up for 12 to 196 months with a rate of 97.13% (169/174).</p><p><b>RESULTS</b>Nine patients showed local recurrence and 14 patients, distant metastasis. The 3-year recurrence rate was 3.79% (5/132), the the 5-year metastasis rate was 10.99% (10/91), and the 5-year survival rate was 92.31% (84/91). Those 3-year recurrence rate for patients without radiotherapy (12.12%) was significantly higher than that with radiotherapy (1.01%), (chi(2) = 5.61, P < 0.05). In patients with node-positive, the the 5-year metastasis rate for patients without chemotherapy (44.44%) was higher than that for those with chemotherapy (6.67%), (P < 0.05). Positive marginal status was associated with local recurrence (P < 0.01). Age at diagnosis of patient with breast cancer (<or= 40 years), node-positive, and histo logical grade III were all highly significant factors of metastasis (P < 0.05).</p><p><b>CONCLUSIONS</b>Radiotherapy must be given after BCT. The patients with positive margin should be treated by re-excision or by mastectomy. Those with young age, node- positive and histological grade III should receive adjuvant chemotherapy.</p>
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WPRIM
Assunto principal:
Patologia
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Prognóstico
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Cirurgia Geral
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Neoplasias da Mama
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Mastectomia Segmentar
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Estudos Retrospectivos
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Seguimentos
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Resultado do Tratamento
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Métodos
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Metástase Neoplásica
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
Idioma:
Zh
Revista:
Chinese Journal of Surgery
Ano de publicação:
2003
Tipo de documento:
Article