Preparation of baicalin-chitooligosaccharide compound and its characterization / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 648-652, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-300175
ABSTRACT
To apply chitooligosaccharide in the preparation of baicalin compound, in order to increase the drug dissolution in vitro, and investigate the basic property of the compound. Baicalin-chitooligosaccharide compound was prepared by using the solvent method. The structure and physicochemical properties of compound were analyzed by using differential scanning calorimetry (DSC), scanning electron microscopy (SEM), X-ray powder diffraction (XRD) and infrared vibrational spectrum (IR), and its dissolution behavior was also investigated. The results showed that the compound prepared at baicalin-chitooligosaccharide molar ratio of 1 1 could significantly improve the dissolution of baicalin. The results of DSC and XRD analysis suggested that baicalin may exist in an amorphous state. IR results indicated the interaction between baicalin and chitooligosaccharide. The baicalin-chitooligosaccharide compound could significantly improve dissolution in vitro of drug.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oligossacarídeos
/
Flavonoides
/
Varredura Diferencial de Calorimetria
/
Portadores de Fármacos
/
Medicamentos de Ervas Chinesas
/
Química
/
Química Farmacêutica
/
Espectroscopia de Infravermelho com Transformada de Fourier
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2014
Tipo de documento:
Artigo
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