Dynamic release of tinidazole from the degradable PLLA-tinidazole blend gel / 华西口腔医学杂志
West China Journal of Stomatology
; (6): 237-239, 2005.
Article
em Zh
| WPRIM
| ID: wpr-300325
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To determine the dynamic release of tinidazole from the degradable poly-lactic acid (PLLA)-tinidazole blend gel (a periodontal local drug delivery) by high-performance liquid chromatography (HPLC) in vitro and to observe the polylactic acid (as a vector of tinidazole) how to affect the release of tinidazole.</p><p><b>METHODS</b>HPLC analysis was conducted. The operating conditions were C18-ODS-A column, water-methanol-acetic acid as mobile phase at a flow rate of 1.5 ml/min and a detection wavelength at 310 nm and a column temperature at 30 degrees C.</p><p><b>RESULTS</b>The retention time of tinidazole was about 12 min. There was good linear relationship between the concentrations of tinidazole in blend gel and their peak areas in the ranges of 5 - 500 mg/L. The regression reaction was y = 0.836 + 8.452 2 x 10(-5) x (r = 0.998 6). RSD was 0.2%. Polylactic acid had no influence on the determination of tinidazole. The daily average release of tinidazole was 5.60%. The cumulative release of tinidazole was about 78.40% in 14 days.</p><p><b>CONCLUSION</b>The in vitro drug release analysis is an useful method in evaluating the performance of local drug delivery system. HPLC analysis is a simple and accurate method with good reproducibility.</p>
Texto completo:
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Índice:
WPRIM
Assunto principal:
Poliésteres
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Polímeros
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Tinidazol
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Reprodutibilidade dos Testes
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Cromatografia Líquida de Alta Pressão
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Ácido Láctico
Idioma:
Zh
Revista:
West China Journal of Stomatology
Ano de publicação:
2005
Tipo de documento:
Article