Diagnosis and treatment of invasive aspergillosis infection following orthotopic liver transplantation / 中华外科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To explore the treatment and appropriate management of invasive aspergillosis infection following orthotopic liver transplantation.</p><p><b>METHODS</b>The clinical data of 576 cases who underwent orthotopic liver transplantation consecutively between January 2000 and January 2005 were analyzed retrospectively.</p><p><b>RESULTS</b>The prevalence of invasive aspergillosis infection was 1.74 (9/576), included 8 cases with pulmonary aspergillosis and 1 case with cerebral aspergillosis. The interval between transplantation and diagnosis were from 10 days to 2 months. Persistent or discontinuous low fever maybe the main clinical presentation after operation. Liposomal amphotericin B (AmBisome) is the mainly treatment for invasive aspergillosis infections, 5 patients were cured and 2 patients developed multi-organ aspergillosis infection died.</p><p><b>CONCLUSIONS</b>The clinical features of invasive aspergillosis infection following orthotopic liver transplantation were un-typical presentations in the early stage and easy to disseminate. Appropriate modification of immunosuppression therapy and early, high dose and long-term application of antifungal treatment is effective and safe to cure the disease.</p>