Research progress on genes mutations related to sulfa drug resistance in / 浙江大学学报·医学版

ABSTRACT

pneumonia is an opportunistic infection among immunocompromised people. Studies have found that the increased resistance to sulfa drugs ofmay be associated with the mutation of dihydropteroate synthase () gene and dihydrofolate reductase () genes, but the mechanism is still unclear. The mutation ofandgenes may be the result of sulfa drugs selection or spontaneous genetic polymorphism, and it can be acquired from person-to-person transmission. This article reviews the cause, molecular epidemiology ofandgene mutation, and the relationship betweenandgene mutation and clinical outcomes.