Research progress on mechanism of Nix-mediated mitophagy / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 92-96, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-300818
ABSTRACT
Autophagy is fundamental to maintain cellular homeostasis. As one kind of the most well-studied selective autophagy, autophagy of mitochondria (mitophagy)is crucial for the clearance of damaged mitochondria. Mitophagy dysfunction has been proved to be closely associated with many human diseases. Nix is a key protein for mitophagy during the maturation of reticulocytes. However, the detailed molecular mechanisms underlying Nix-mediated mitophagy are not fully understood. This article summarizes three possible working models of Nix in mitophagy induction. Firstly, Nix can interplay with Parkin, another important protein for mitophagy, to initiate mitophagy. Secondly, Nix can serve as a receptor for autophagy machinery by interacting with Atg8 family through its LIR motif. Finally, as a BH3-only protein, Nix can compete with Beclin-1 to bind other members of Bcl-2 family resulting in increased free Beclin-1 in cytosol, which further promotes autophagy flux.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Autofagia
/
Proteínas Proto-Oncogênicas
/
Proteínas Proto-Oncogênicas c-bcl-2
/
Proteínas Supressoras de Tumor
/
Ubiquitina-Proteína Ligases
/
Domínios e Motivos de Interação entre Proteínas
/
Mitofagia
/
Proteína Beclina-1
/
Família da Proteína 8 Relacionada à Autofagia
Idioma:
Chinês
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2017
Tipo de documento:
Artigo
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