Localization of vesicular glutamate transporters in the peripheral vestibular system of rat / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 175-179, 2007.
Artigo
em Inglês
| WPRIM
| ID: wpr-300980
ABSTRACT
<p><b>OBJECTIVE</b>To examine the vesicular glutamate transporters (VGluTs VGluT1-VGluT3) in the peripheral vestibular system.</p><p><b>METHODS</b>The vestibular structures, including Scarpa's ganglion (vestibular ganglion, VG), maculae of utricle and saccule, and ampullary cristae, from normal Sprague-Dawley rats were processed immunohistochemically for VGluTs, by avidin-biotinylated peroxidase complex method, with 3-3'-diaminobenzidine (DAB) as chromogen.</p><p><b>RESULTS</b>(1) VGluT1 was localized to partial neurons of VG and to the putative primary afferent fibers innervating vestibular end-organs. (2) Intense VGluT3 immunoreactivity was detected in large number of sensory epithelia cells, and weak labeling of VGluT3-positive afferent fibers was in the maculae and ampullary cristae. (3) No or very weak VGluT2 immunoreactivity was observed in the VG and acoustic maculae.</p><p><b>CONCLUSION</b>These results provide the morphological support that glutamate exists in the peripheral vestibular system, and it may play an important role in the centripetal vestibular transmission.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Nervo Vestibulococlear
/
Máculas Acústicas
/
Vestíbulo do Labirinto
/
Classificação
/
Ratos Sprague-Dawley
/
Biologia Celular
/
Proteínas Vesiculares de Transporte de Glutamato
/
Metabolismo
/
Neurônios
Limite:
Animais
Idioma:
Inglês
Revista:
Neuroscience Bulletin
Ano de publicação:
2007
Tipo de documento:
Artigo
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