Modulation of the suppressive effect of corticosterone on adult rat hippocampal cell proliferation by paroxetine / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 131-136, 2007.
Artigo
em Inglês
| WPRIM
| ID: wpr-300987
ABSTRACT
<p><b>OBJECTIVE</b>The literature has shown that cognitive and emotional changes may occur after chronic treatment with glucocorticoids. This might be caused by the suppressive effect of glucocorticoids on hippocampal neurogenesis and cell proliferation. Paroxetine, a selective serotonin reuptake transporter, is a commonly used antidepressant for alleviation of signs and symptoms of clinical depression. It was discovered to promote hippocampal neurogenesis in the past few years and we wanted to investigate its interaction with glucocorticoid in this study.</p><p><b>METHODS</b>Adult rats were given vehicle, corticosterone, paroxetine, or both corticosterone and paroxetine for 14 d. Cell proliferation in the dentate gyrus was quantified using 5-bromo-2-deoxyuridine (BrdU) immunohistochemistry.</p><p><b>RESULTS</b>The corticosterone treatment suppressed while paroxetine treatment increased hippocampal cell proliferation. More importantly, paroxetine treatment could reverse the suppressive effect of corticosterone on hippocampal cell proliferation.</p><p><b>CONCLUSION</b>This may have clinic application in preventing hippocampal damage after glucocorticoid treatment.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Bromodesoxiuridina
/
Corticosterona
/
Contagem de Células
/
Análise de Variância
/
Inibidores Seletivos de Recaptação de Serotonina
/
Ratos Sprague-Dawley
/
Paroxetina
/
Biologia Celular
/
Proliferação de Células
Limite:
Animais
Idioma:
Inglês
Revista:
Neuroscience Bulletin
Ano de publicação:
2007
Tipo de documento:
Artigo
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