Study on preparation conditions for polylactide nanoparticles loaded cyclosporine A and its oral bioavailability in rats / 药学学报
Acta Pharmaceutica Sinica
; (12): 68-71, 2004.
Article
em Zh
| WPRIM
| ID: wpr-301146
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>AIM</b>To develop a less toxic alternative for sandimmun neoral (Neoral). To study the preparation conditions and to compare its pharmacokinetic characteristics with Neoral.</p><p><b>METHODS</b>Polylactide nanoparticles loaded cyclosporine A was prepared by solvent-nonsolvent method. Polylactide nanoparticles were administered by oral in a dosage of 15 mg.kg-1. The CyA concentration in whole blood sample was determined by HPLC.</p><p><b>RESULTS</b>The quantities of CyA, PLA and volume of acetone added had significant influence on the NP diameters. Under proper condition, the nanoparticles with diameters of 57.5 nm were obtained. The relative bioavailability in rats was 101.6%, with a smaller absorption rate (P < 0.05) and a smaller elimination rate (P < 0.1).</p><p><b>CONCLUSION</b>The nanoparticles (diamater < 100 nm) with relative high bioavailability were prepared using solvent-nonsolvent method. It is suitable for further study.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Poliésteres
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Farmacocinética
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Disponibilidade Biológica
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Distribuição Aleatória
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Administração Oral
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Ciclosporina
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Ratos Wistar
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Nanotecnologia
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Preparações de Ação Retardada
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Imunossupressores
Limite:
Animals
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2004
Tipo de documento:
Article