Antagonistic effect of sodium ferulate on glycerol-induced renal oxidative injury in mice / 药学学报
Acta Pharmaceutica Sinica
;
(12): 900-903, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-301180
ABSTRACT
<p><b>AIM</b>To investigate the effect of sodium ferulate (SF) on glycerol-induced renal injury.</p><p><b>METHODS</b>Glycerol solution 50% was injected intramuscularly to establish a model of acute tubular necrosis in mice. SF was administered intraperitoneally at the dose of 100-200 mg.kg-1 at the beginning of establishing the model and its effect was observed by monitoring renal function, antioxidative functions and renal pathologic histology.</p><p><b>RESULTS</b>At 6 and 72 h after glycerol injection, SF treatment (100-200 mg.kg-1) showed significant and dose-dependent antagonistic actions on the increment of blood urea nitrogen (BUN), creatinine (Cr), and N-acetyl-beta-glucosaminidase (NAG) induced by glycerol. The increase of renal malondialdehyde (MDA) content and the decrease of glutathione content, glutathione peroxidase (GSH-Px), glutathione S-transferase (GST), catalase (Cat) and superoxide dismutase (SOD) activities resulting from glycerol injection were remarkably inversed by SF at the dose of 200 mg.kg-1. Meanwhile, improvement of the renal histology was observed as well.</p><p><b>CONCLUSION</b>SF showed beneficial effect on glycerol-induced acute tubular necrosis due to its antioxidative action.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Superóxido Dismutase
/
Sangue
/
Nitrogênio da Ureia Sanguínea
/
Ácidos Cumáricos
/
Creatinina
/
Glutationa Peroxidase
/
Glicerol
/
Rim
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2003
Tipo de documento:
Artigo
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