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The effect of cyclosporine A on lipopolysaccharide-induced acute lung injury in mice / 中国应用生理学杂志
Chinese Journal of Applied Physiology ; (6): 120-123, 2011.
Artigo em Chinês | WPRIM | ID: wpr-301486
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of mitochondrial permeability transition pore inhibitor cyclosporine A (CsA) on lipopolysaccharide (LPS)-induced acute lung injury in mice.</p><p><b>METHODS</b>All male ICR mice were randomly divided into five groups (n = 24) control group, LPS group, dexamethasone group, cyclosporine A(CsA) group and CsA + atractyloside(Atr) group. Six hours after treatment with LPS, the activity of lactate dehydrogenlase (LDH) in bronchoalveolar lavage fluid (BALF) and level of tumor necrosis factor-alpha (TNF-alpha) in lung tissue were detected. The lung wet weight/dry weight ratio and the pulmonary capillary permeability index were also detected.</p><p><b>RESULTS</b>In contrast to LPS group, the mitochondrial permeability transition pore inhibitor CsA induced a decrease in LDH activity in the BALF and TNF-alpha level in lung tissue, lung wet weight/dry weight ratio and the pulmonary capillary permeability index were declined. Atractyloside, the activator of mitochondrial permeability transition pore, almost abolished the role of CsA on LPS-induced lung injury.</p><p><b>CONCLUSION</b>These results suggested that CsA plays the protective effect on LPS-induced lung injury in mice, it is likely through inhibiting the opening of mitochondrial permeability transition pore.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Lipopolissacarídeos / Fator de Necrose Tumoral alfa / Ciclosporina / Substâncias Protetoras / Proteínas de Transporte da Membrana Mitocondrial / Lesão Pulmonar Aguda / L-Lactato Desidrogenase / Metabolismo / Camundongos Endogâmicos ICR Limite: Animais Idioma: Chinês Revista: Chinese Journal of Applied Physiology Ano de publicação: 2011 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Lipopolissacarídeos / Fator de Necrose Tumoral alfa / Ciclosporina / Substâncias Protetoras / Proteínas de Transporte da Membrana Mitocondrial / Lesão Pulmonar Aguda / L-Lactato Desidrogenase / Metabolismo / Camundongos Endogâmicos ICR Limite: Animais Idioma: Chinês Revista: Chinese Journal of Applied Physiology Ano de publicação: 2011 Tipo de documento: Artigo