The protective effect of melatonin on auditory cortex toxicity induced by cis-platinum / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 539-542, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-301566
ABSTRACT
<p><b>AIM</b>To investigate the toxic response in auditory cortex of guinea pigs caused by cis-platinum (DDP), and the protective role of melatonin in this effect.</p><p><b>METHODS</b>Cis-platinum and melatonin were injected peritoneally. LDH, MDA, NO in the auditory cortex were detected by spectrophotometeR.</p><p><b>RESULTS</b>The body weight of the guinea pigs was diminished by peritoneal injection of Cis-platinum for 7 days (P < 0.01). Peritoneal injection of Cis-platinum induced the increased leakage of LDH (P < 0.05 vs injection of normal saline). This effect was reduced by injection of MT (P < 0.05). The content of MDA in the auditory cortex was also increased because of injection of Cis-platinumv for 7 days (P < 0.01) and MT reduced this effect (P < 0.05). The change of NO in the auditory cortex was not statistically significant after injection of Cis-platinum or Cis-platinum with MT.</p><p><b>CONCLUSION</b>Peritoneal injection of Cis-platinum could destroy neurons in the auditory cortex. This effect could be reduced by melatonin by an anti-free radials mechanism.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Córtex Auditivo
/
Distribuição Aleatória
/
Sequestradores de Radicais Livres
/
Cisplatino
/
Toxicidade
/
Cobaias
/
Malondialdeído
/
Melatonina
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2009
Tipo de documento:
Artigo
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