Utilization of targeting specific proteins for ubiquitination and degradation / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 123-127, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-301582
ABSTRACT
Ubiquitin-proteasome pathway (UPP) can degrade specific proteins in eukaryotic cells. Targeting specific proteins for ubiquitination and degradation technique, based the theory of UPP and using certain chimeric E3s or protein-targeting chimeric molecules, can specifically knock down the targeted proteins. It is a promising new method for exploring the functions of genes or proteins and, together with gene-silencing technique, may play an important role in basic and clinical research.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ligação Proteica
/
Proteínas Recombinantes
/
Transporte Proteico
/
Ubiquitina-Proteína Ligases
/
Complexo de Endopeptidases do Proteassoma
/
Ubiquitinação
/
Metabolismo
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2010
Tipo de documento:
Artigo
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