Current situation researching of methylation in tumor / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 786-790, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-301607
ABSTRACT
The disorders of DNA and histone methylation have a close relationship with the development and progression of tumors. Epigenetic regulation is critical in maintaining the stability and integrity of the expression profiles of different cell types by modifying DNA methylation and histone methylation. However, the abnormal changes of methylation often result in the development and progression of tumors. This review summarized the theory of tumor genomic and histone methylation, detection methods of methylation and their applications, and the clinical application of methylation as biological markers and drug targets.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Histonas
/
Metilação de DNA
/
Genética
/
Metabolismo
/
Metilação
/
Neoplasias
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2009
Tipo de documento:
Artigo
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