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Frequency of factor VIII inhibitor in the patients with hemophilia A and environmental risk factors for inhibitor development / 中国医学科学院学报
Acta Academiae Medicinae Sinicae ; (6): 580-583, 2009.
Artigo em Chinês | WPRIM | ID: wpr-301647
ABSTRACT
<p><b>OBJECTIVE</b>To screen for factor VIII inhibitor in patients with hemophilia A (HA) and explore the environmental risk factors for inhibitor development.</p><p><b>METHODS</b>Totally 265 patients with HA were enrolled, including 107 consecutive inpatients and outpatients in Peking Union Medical College Hospital from April 2003 to April 2007 and 158 patients newly recruited from other hospitals. FVIII C activity was measured by one-stage coagulation assay. FVIII inhibitor was determined using Bethesda method.</p><p><b>RESULTS</b>In 265 HA patients, FVIII inhibitor was detected in 22 patients (8.3%). Nine of them (86.4%) were low responders (inhibitor titers < or = 5 000 BU/L), 3 (13.6%) were high responders (the titers > 5 000 BU/L). The frequency of FVIII inhibitor was 50% in the patients aged over 50 years, which was significantly higher than those in other age groups (P = 0. 000). Among 158 newly recruited patients with full clinical data, the frequency of FVIII inhibitor was 12.8% in patients who had received infusion of FVIII products for more than 12 doses on average each year, while it was 5.8% in whom the infusion doses were less than 12 (P = 0.156). The frequency of FVIII inhibitor was 28.5% in patients with a history of continuous infusion of FVIII products whereas it was only 1.6% in patients without such history (P = 0.000). In patients who exposed to multiple-branded or single-branded FVIII products, the frequencies of FVIII inhibitor were 9.3% and 3.9%, respectively (P = 0.229).</p><p><b>CONCLUSION</b>The development of factor VIII inhibitor in patients with hemophilia A may be related to the age and the history of continuous infusion of FVIII products.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Sangue / Fator VIII / Fatores de Risco / Meio Ambiente / Hemofilia A Tipo de estudo: Estudo de etiologia / Fatores de risco Limite: Adolescente / Adulto / Idoso / Criança / Criança, pré-escolar / Humanos / Lactente / Masculino Idioma: Chinês Revista: Acta Academiae Medicinae Sinicae Ano de publicação: 2009 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Sangue / Fator VIII / Fatores de Risco / Meio Ambiente / Hemofilia A Tipo de estudo: Estudo de etiologia / Fatores de risco Limite: Adolescente / Adulto / Idoso / Criança / Criança, pré-escolar / Humanos / Lactente / Masculino Idioma: Chinês Revista: Acta Academiae Medicinae Sinicae Ano de publicação: 2009 Tipo de documento: Artigo