Changes of insulin resistance and islet beta cells function in subjects with high-normal blood pressure / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 494-497, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-301665
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the changes of insulin resistance and islet beta cells function in subjects with euglycemia and high-normal blood pressure.</p><p><b>METHODS</b>Total 423 subjects were divided into normal blood pressure group and high-normal blood pressure group. Body height, weight, waist and hip circumference, and biochemical data were measured. Homeostasis model assessment of insulin resistance (HOMA-IR), insulin sensitivity index (ISI)-composite, and first-phase (1 PH) Stumvoll index were calculated. Results Waist circumference, total cholesterol, triglyceride, low-density lipoprotein cholesterol, HOMA-IR were significantly higher and IPH Stumvoll index and ISI-composite were significantly lower in high-normal blood pressure group than in normal blood pressure group (P < 0.05). Systolic blood pressure (SBP) was positively correlated with HOMA-IR (r = 0.122) and negatively correlated with 1PH Stumvoll index (r = -0. 159) and ISI-composite (r = -0.131) (P < 0.05). SBP and triglyceride were independent factors for IPH Stumvoll index.</p><p><b>CONCLUSION</b>Insulin resistance and islet dysfunction may exist in subjects with high-normal blood pressure.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Triglicerídeos
/
Sangue
/
Pressão Sanguínea
/
Peso Corporal
/
Resistência à Insulina
/
Índice de Massa Corporal
/
Colesterol
/
Circunferência da Cintura
/
Hipertensão
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2009
Tipo de documento:
Artigo
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