Hedgehog signaling pathway and osteoporosis / 中国骨伤
China Journal of Orthopaedics and Traumatology
; (12): 169-172, 2014.
Article
em Zh
| WPRIM
| ID: wpr-301865
Biblioteca responsável:
WPRO
ABSTRACT
Hedgehog signaling pathway is a conserved and important signaling pathway involved in proliferation and differentiation of many types of cells. Latest studies have found that Hedgehog signaling pathway may induce MSCs osteoblast differentiation by increasing the expression of the Runx2 and Osx and inhibit MSCs differentiate to adipocyte. Hedgehog signaling pathway may also promote osteoblast proliferation by regulating cyclin. This review summarizes the mechanism that Hedgehog signaling pathway regulates osteoblast differentiation and proliferation,and concludes that Hedgehog signaling pathway can regulate bone metabolism. It might provide new ideas for the treatment of osteoporosis.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Osteoblastos
/
Osteoporose
/
Fisiologia
/
Fatores de Transcrição
/
Transdução de Sinais
/
Diferenciação Celular
/
Biologia Celular
/
Tratamento Farmacológico
/
Subunidade alfa 1 de Fator de Ligação ao Core
/
Proteínas Hedgehog
Limite:
Humans
Idioma:
Zh
Revista:
China Journal of Orthopaedics and Traumatology
Ano de publicação:
2014
Tipo de documento:
Article