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Correlation between epidermal growth factor and overexpression of vascular endothelial growth factor in hepatocellular carcinoma / 中华肿瘤杂志
Chinese Journal of Oncology ; (12): 564-566, 2002.
Artigo em Chinês | WPRIM | ID: wpr-301935
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the correlation between epidermal growth factor (EGF) and overexpression of vascular endothelial growth factor (VEGF) in hepatocellular carcinoma (HCC).</p><p><b>METHODS</b>Expressions of EGF, VEGF and microvessel density were studied through immunohistochemical SABC method in 36 HCC specimens, their paraneoplastic liver tissues and 6 normal liver tissues with the correlation between these parameters analyzed. Recombinant human EGF was used to stimulate HepG(2) cells and semi-quantitative reverse transcription PCR was adopted to detect the expression of VEGF in HepG(2) cells.</p><p><b>RESULTS</b>The positive rates of EGF and VEGF expression in HCC tissue were 75.0% and 88.9%. There was positive correlation between EGF and VEGF expression (P < 0.01, r = 0.462). Recombinant human EGF could induce the expression of VEGF in HepG(2) cells in a dose and time dependent manner.</p><p><b>CONCLUSION</b>The expression of EGF in HCC underlies the overexpression of VEGF in HCC.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Estatística como Assunto / Fatores de Crescimento Endotelial / Linfocinas / Carcinoma Hepatocelular / Peptídeos e Proteínas de Sinalização Intercelular / Fatores de Crescimento do Endotélio Vascular / Fator A de Crescimento do Endotélio Vascular / Fator de Crescimento Epidérmico / Neoplasias Hepáticas / Metabolismo Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Oncology Ano de publicação: 2002 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Estatística como Assunto / Fatores de Crescimento Endotelial / Linfocinas / Carcinoma Hepatocelular / Peptídeos e Proteínas de Sinalização Intercelular / Fatores de Crescimento do Endotélio Vascular / Fator A de Crescimento do Endotélio Vascular / Fator de Crescimento Epidérmico / Neoplasias Hepáticas / Metabolismo Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Oncology Ano de publicação: 2002 Tipo de documento: Artigo