Expressions of beta-catenin, p53 and proliferating cell nuclear antigen in the carcinogenesis of colorectal adenoma / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 264-267, 2002.
Article
em Zh
| WPRIM
| ID: wpr-301958
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>Research was done on the possible roles of beta-catenin, p53 and proliferating cell nuclear antigen (PCNA) in the carcinogenesis of colorectal adenoma (CRA).</p><p><b>METHODS</b>beta-catenin and p53 and PCNA expressions were studied with immunohistochemical stain in 77 specimens of CRA together with mild epithelial dysplasia (CRA-MD), CRA with moderate/severe epithelial dysplasia (CRA-D/SD) and CRA with cancerous changes (CRA-C).</p><p><b>RESULTS</b>The percentage of abnormal expression of beta-catenin increased during the transition from CRA-MD to CRA-D/SD to CRA-C (P < 0.01). The nuclear expressions of beta-catenin in CRA-D/SD and CRA-C were all significantly higher than that in CRA-MD. Expression of p53 and PCNA were increased from CRA-MD to CRA-D/SD to CRA-C, with the positive rates in these three groups of 10.3%, 43.8%, 75.0% for p53 and 17.2%, 62.5%, 87.5% for PCNA, respectively. 69.7% of cases with positive nuclear beta-catenin expression showed strong PCNA positivity which was much higher than the 36.4% of cases without nuclear beta-catenin expression (P < 0.05). The percentage of strong PCNA expression in the p53 positive cases was significant higher than that in cases with negative p53 expression (72.4% vs 37.5%, P < 0.05). Nuclear beta-catenin and p53 co-expression rates in CRA-C reached 50%.</p><p><b>CONCLUSION</b>beta-catenin, p53 and PCNA may play important roles in the carcinogenesis of colorectal adenoma.</p>
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Índice:
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Assunto principal:
Prognóstico
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Imuno-Histoquímica
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Neoplasias Colorretais
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Biomarcadores Tumorais
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Transativadores
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Proteína Supressora de Tumor p53
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Antígeno Nuclear de Célula em Proliferação
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Proteínas do Citoesqueleto
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Diagnóstico
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Beta Catenina
Tipo de estudo:
Diagnostic_studies
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Prognostic_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Oncology
Ano de publicação:
2002
Tipo de documento:
Article