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Correlation between gene polymorphism of endothelial protein C receptor and cerebral infarction in Chinese Han population of Hubei province / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 203-205, 2009.
Artigo em Chinês | WPRIM | ID: wpr-302166
ABSTRACT
In order to explore the distribution frequency of endothelial protein C receptor (EPCR) gene A6936G variant and to study the correlation between this mutation and cerebral infarction in Chinese Han population of Hubei province district. The genotype and allele frequencies of EPCR A6936G were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 380 cerebral infarction patients and 380 healthy Chinese Han persons. The results indicated that the frequencies of A/A, A/G and G/G genotypes in cerebral infarction group were 77.1%, 22.1% and 0.8% respectively. While the frequencies of A/A and A/G genotypes in control group were 88.2% and 11.8%, and without G/G genotype. It is concluded that A6936G polymorphism of EPCR can be detected in Chinese Han population of Hubei province district, which may be correlated with the increasing risk of thrombosis in cerebral infarction patients.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Polimorfismo Genético / Antígenos CD / Estudos de Casos e Controles / Infarto Cerebral / Receptores de Superfície Celular / Povo Asiático / Receptor de Proteína C Endotelial / Frequência do Gene / Genética / Genótipo Tipo de estudo: Estudo observacional / Fatores de risco Limite: Adulto / Idoso / Aged80 / Feminino / Humanos / Masculino Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2009 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Polimorfismo Genético / Antígenos CD / Estudos de Casos e Controles / Infarto Cerebral / Receptores de Superfície Celular / Povo Asiático / Receptor de Proteína C Endotelial / Frequência do Gene / Genética / Genótipo Tipo de estudo: Estudo observacional / Fatores de risco Limite: Adulto / Idoso / Aged80 / Feminino / Humanos / Masculino Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2009 Tipo de documento: Artigo