Relationship between the U wave on electrocardiogram and the midmyocardium of the left ventricular wall / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 509-512, 2002.
Artigo
em Inglês
| WPRIM
| ID: wpr-302265
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between the U wave on electrocardiogram and the midmyocardium in rabbit left ventricle free wall in vivo.</p><p><b>METHODS</b>The monophasic action potentials in the epicardium, midmyocardium, and endocardium of the left ventricle free wall were recorded simultaneously in 16 rabbits. The rabbits were then given an intravenous injection of Sotalol (1, 1.5 and 2.0 mg/kg) in 30 minutes intervals, and measurements were taken.</p><p><b>RESULTS</b>In the basic condition, there were no U wave on electrocardiogram. The U wave appeared after the intravenous Sotalol at 1.5 mg/kg, and the U wave became greater with increased dosage of intravenous Sotalol (2 mg/kg). The repolarization duration of the midmyocardium was prolonged longer than that of the epicardium and endocardium by Sotalol, and the repolarization duration of the epicardium coincided with the apex of the T wave, The repolarization duration of the midmyocardium coincided with the end point of the U wave.</p><p><b>CONCLUSION</b>The U wave may originate from the delayed repolarization of the midmyocardium.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pericárdio
/
Farmacologia
/
Fisiologia
/
Sotalol
/
Potenciais de Ação
/
Função Ventricular
/
Relação Dose-Resposta a Droga
/
Eletrocardiografia
/
Endocárdio
/
Ventrículos do Coração
Limite:
Animais
Idioma:
Inglês
Revista:
Chinese Medical Journal
Ano de publicação:
2002
Tipo de documento:
Artigo
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