Research advances on ADAM28 expression and ADAM28-mediated tumor metastasis / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1142-1147, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-302331
ABSTRACT
A disintegrin-metalloproteinase 28 (ADAM28) is one of important members of ADAM family, that is involved in various biological events including cell adhesion, proteolysis, growth and metastasis of solid tumors and hematological malignancies. Studies have shown that ADAM28 is highly expressed in several human tumors, such as lung, breast and bladder cancers, and chronic lymphocytic leukemia, and its tissue expression levels correlate with cancer metastasis. ADAM28-mediated cancer cell metastasis may be related with the cleavage of von Willebrand's factor (vWF), insulin-like growth factor binding protein-3 (IGFBP-3) and connective tissue growth factor (CTGF), as well as the promoting PSGL-1/P-selectin-mediated cell adhesion. This review summarizes the basic and translational aspects of ADAM28 biology that might stimulate the interest in ADAM28 research and discovery of novel ADAM28 targets, providing potential novel therapies for metastatic cancers.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Fator de von Willebrand
/
Adesão Celular
/
Proteína 3 de Ligação a Fator de Crescimento Semelhante à Insulina
/
Proteínas ADAM
/
Fator de Crescimento do Tecido Conjuntivo
/
Metabolismo
/
Metástase Neoplásica
/
Neoplasias
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2014
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS