Synthesis and anti-active oxygen properties of water-soluble metal porphyrins / 药学学报
Acta Pharmaceutica Sinica
;
(12): 711-715, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-302731
ABSTRACT
<p><b>AIM</b>To synthesize four water-soluble metal porphyrins [5, 10, 15, 20-tetra[4-(4'-pyridine-1) butyloxy phenyl] metalloporphyrins bromide, metal = Zn (I), Cu (II), Mn (III) and Co (IV)] as analogous enzyme having two anti-active oxygen functions.</p><p><b>METHODS</b>The first function, scavenging O2-, has been proved by using riboflavine-methionine photoreduction methods. The second function, scavenging H2O2, has been demonstrated by using the oxidating Vit C. The third function, scavenging HO*, has been demonstrated by using Fenton reaction. The complexes were measured by the mice liver homogenate technique of mice.</p><p><b>RESULTS</b>Four model compounds could scavenge O2- in the concentration range of 1.0 x 10(-5) - 1.0 x 10(-6) mol x L(-1), decompose H2O2 in the concentration of 1.5 x 10(-6) - 1.0 x 10(-6) mol x L(-1), scavenge HO* in the concentration of 2.0 x 10(-8) - 1.0 x 10(-8) mol x L(-1). All showed that they had obvious action of decreasing the lipid peroxidation in the concentration of 1.0 x 10(-7) mol x L(-1).</p><p><b>CONCLUSION</b>All above-mentioned complexes were considered to be qualified analogous enzymes of anti-active oxygen.</p>
Texto completo:
DisponíveL
Índice:
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Assunto principal:
Farmacologia
/
Zinco
/
Técnicas In Vitro
/
Peroxidação de Lipídeos
/
Sequestradores de Radicais Livres
/
Espécies Reativas de Oxigênio
/
Cobalto
/
Radical Hidroxila
/
Cobre
/
Peróxido de Hidrogênio
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2004
Tipo de documento:
Artigo
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