Characterization of Me. PEG-PLA copolymer nanoparticles prepared by modified spontaneous emulsion-solvent evaporation / 药学学报
Acta Pharmaceutica Sinica
;
(12): 677-680, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-302738
ABSTRACT
<p><b>AIM</b>Characterization of poly (D, L-lactic acid)/monomethylether terminated/polyethylene glycol (Me. PEG-PLA) block copolymers nanoparticles.</p><p><b>METHODS</b>Me. PEG-PLA block copolymers were prepared by bulk polymerization. A series of nanoparticles were made from Me. PEG-PLA block copolymer by modified spontaneous emulsion-solvent evaporation technique.</p><p><b>RESULTS AND CONCLUSION</b>The structure of copolymer was performed by means of 1HNMR and FT-IR. The morphological examination of nanoparticles was performed by means of atomic force microscope (AFM). Results indicated that nanoparticles exhibited a smooth spherulite and core-shell structure. The hydrophilic shell is consisted of PEG segments and hydrophobic core is consisted of PLA segments. Zeta potential of nanoparticles was zero and further indicated core-shell structure. The particle size and size distribution of nanoparticles were measured by laser light scattering technique. The effective particle size range was from 70 to 160 nm and showed a normal distribution.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tamanho da Partícula
/
Poliésteres
/
Polietilenoglicóis
/
Portadores de Fármacos
/
Química
/
Microscopia de Força Atômica
/
Nanotecnologia
/
Composição de Medicamentos
/
Emulsões
/
Métodos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2004
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS