Studies on the chemical constituents of Evodia rutaecarpa (Juss.) Benth / 药学学报

ABSTRACT

<p><b>AIM</b>To study the chemical constituents of Evodia rutaecarpa (Juss.) Benth.</p><p><b>METHODS</b>The crude total alkaloids were enriched by acid-base treatment and solvent extraction. Isolation and purification were carried out by silica gel column chromatography and recrystallization etc. Structural determination of the pure compounds were based on physico-chemical properties and various spectral data analysis (1HNMR, 13CNMR, UV, IR, 1H-1H COSY, HMQC, HMBC, ESIMS, HREIMS, NOESY).</p><p><b>RESULTS</b>Fourteen compounds were obtained from Evodia rutaecarpa, ten of them were identified as evodianinine (1), rutaecarpine (2), evodiamine (3), wuchuyuamide I (4), hydroxyevodiamine (5), limonin (6), daucosterol (7), triacontanoic acid (8), nonacosane (9) and beta-sitosterol (10).</p><p><b>CONCLUSION</b>Compound 1 is a new alkaloid named evodianinine.</p>