Synthesis and antitumor activity of 20-O-linked camptothecin ester derivatives / 药学学报
Acta Pharmaceutica Sinica
;
(12): 591-597, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-302756
ABSTRACT
<p><b>AIM</b>To improve the profile of 20 (S)-camptothecin, a series of 20-O-linked camptothecin phenoxyacetic acid ester derivatives have been designed.</p><p><b>METHODS</b>These derivatives were synthesized by the method of acylation. Their chemical structures were confirmed with 1HNMR, IR, MS, and HRMS. The cytotoxicities of the compounds were tested by MTT assay. The in vivo antitumor activities of these esters were evaluated against mouse liver tumor H22 in mice.</p><p><b>RESULTS</b>Twelve derivatives of camptothecin ester are new compounds.</p><p><b>CONCLUSION</b>In vitro and in vivo antitumor activity has indicated that some derivatives appeared significantly more effective than topotecan in the H22 mouse liver tumoral model.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Camptotecina
/
Estrutura Molecular
/
Química
/
Topotecan
/
Concentração Inibidora 50
/
Ensaios Antitumorais Modelo de Xenoenxerto
/
Linhagem Celular Tumoral
/
Carga Tumoral
Limite:
Animais
/
Feminino
/
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2004
Tipo de documento:
Artigo
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