Studies on chiral inversion of dextropantoprazole in human / 药学学报
Acta Pharmaceutica Sinica
;
(12): 370-373, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-302806
ABSTRACT
<p><b>AIM</b>To study the chiral inversion of dextropantoprazole in human.</p><p><b>METHODS</b>Three healthy Chinese male volunteers after an oral dose of 40 mg dextropantoprazole. An HPLC method was developed and used to determine the total plasma concentrations of each enantiomer. The ratios of the enantiomers in plasma samples were measured on a Chiral-AGP column. The plasma concentration of each enantiomer was then calculated using the ratios of enantiomers and total concentrations of the two enantiomers previously measured.</p><p><b>RESULTS</b>The AUC0-t of levopantoprazole was only 1.5% of the total AUC0-t of enantiomers.</p><p><b>CONCLUSION</b>The chiral inversion from dextropantoprazole to levopantoprazole does not occur in the three healthy Chinese male volunteers after an oral dose of 40 mg dextropantoprazol.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Estereoisomerismo
/
Sulfóxidos
/
Benzimidazóis
/
Sangue
/
Omeprazol
/
Farmacocinética
/
Química
/
Administração Oral
/
Cromatografia Líquida de Alta Pressão
/
Área Sob a Curva
Tipo de estudo:
Estudo prognóstico
Limite:
Adulto
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2004
Tipo de documento:
Artigo
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