Your browser doesn't support javascript.
loading
Significance of CD138 in immunohistochemical profiles and its correlation with prognosis in diffuse large B-cell lymphoma / 中华肿瘤杂志
Chinese Journal of Oncology ; (12): 115-120, 2011.
Artigo em Chinês | WPRIM | ID: wpr-303355
ABSTRACT
<p><b>OBJECTIVE</b>The purpose of this study was to classify the diffuse large B-cell lymphoma (DLBCL) into different prognostic subgroups according to four different detection methods of the expression of CD138, CD10, bcl-6, and MUM1. In particular to investigate the significance of CD138 in immunohistochemical profiles and its correlation with prognosis in DLBCL.</p><p><b>METHODS</b>Immunohistochemical EnVision method was used to detect the expression of CD138, CD10, bcl-6 and MUM1 in 106 cases of DLBCL and reconstructed into four different subtyping algorithms. Algorithm-1, according to the expression of CD10, bcl-6 and MUM1, the cases were assigned to GCB and non-GCB groups. Algorithm-2, according to the expression of CD138, CD10, bcl-6 and MUM1, the cases were assigned to A, B, C, D groups. Algorithm-3, according to the expression of CD10 and MUM1, the cases were assigned to GCB and non-GCB groups. Algorithm-4, according to the expression of CD138, CD10, bcl-6 and MUM1, the cases were assigned to GCB and non-GCB groups. Following up was included as well. Statistical analysis was performed using the SPSS 13.0 and differences were considered significant at P < 0.05.</p><p><b>RESULTS</b>CD138, MUM1, CD10 and bcl-6 were positive in 15.1% (16/106), 56.6% (60/106), 21.7 (23/106) and 26.4% (28/106), respectively. The expression of CD10 and bcl-6 was associated with favorable OS (P = 0.001 and 0.041, respectively), whereas the expression of CD138 was associated with unfavorable OS (P = 0.003). Using multivariate Cox proportional hazards regression analysis, algorithm-1 and -4 were almost at the same level for prognosis of OS (OR = 0.259, 0.255) and PFS (OR = 0.248, 0.244).</p><p><b>CONCLUSIONS</b>Both Hans's algorithm and Colombo's algorithm including CD138 detection are associated with the prognosis of DLBCL patients. The two algorithms have similar OR value according to Cox analysis. However, positive expression of CD138 is of minor significance in prediction of the prognosis in DLBCL patients.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Prognóstico / Imuno-Histoquímica / Linfoma de Células B / Linfoma Difuso de Grandes Células B / Sindecana-1 / Metabolismo Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Chinês Revista: Chinese Journal of Oncology Ano de publicação: 2011 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Prognóstico / Imuno-Histoquímica / Linfoma de Células B / Linfoma Difuso de Grandes Células B / Sindecana-1 / Metabolismo Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Chinês Revista: Chinese Journal of Oncology Ano de publicação: 2011 Tipo de documento: Artigo