Effect of fibrinogen on the adherence of Porphyromonas gingivalis to human oral epithelial cells / 中华口腔医学杂志
Chinese Journal of Stomatology
; (12): 69-73, 2006.
Article
em Zh
| WPRIM
| ID: wpr-303430
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the role of fibrinogen molecule in the pathogenesis of periodontal diseases.</p><p><b>METHODS</b>An in vitro cell culture model was used. Methyl-(3)H Thymidine radiolabeled Porphyromonas gingivalis (Pg) ATCC 33277 were examined for their ability to adhere to and invade the confluent monolayers of human oral epithelial KB cells with or without exogenous human fibrinogens by scintillation spectrometry.</p><p><b>RESULTS</b>The addition of exogenous fibrinogens made more amount of and higher ratios of adhesive and invasive Pg, in contrast to the group without exogenous fibrinogen (P < 0.001). At different concentrations of exogenous fibrinogen, the amount and ratios of adhesive and invasive Pg varied significantly (P < or = 0.007). The higher concentrations of exogenous fibrinogen was added, the greater amount and ratios of adhesive and invasive Pg were found.</p><p><b>CONCLUSIONS</b>Fibrinogen promotes the adherence of Pg to human oral epithelial cells and may play an important role in the pathogenesis of periodontal diseases.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Periodontite
/
Farmacologia
/
Virulência
/
Aderência Bacteriana
/
Fibrinogênio
/
Células KB
/
Porphyromonas gingivalis
/
Microbiologia
/
Mucosa Bucal
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Stomatology
Ano de publicação:
2006
Tipo de documento:
Article