Inhibition of Ehrlich ascites carcinoma by Manilkara zapota L. stem bark in Swiss albino mice
Asian Pacific Journal of Tropical Biomedicine
;
(12): 448-451, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-303641
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the antitumor activity of Manilkara zapota (M. zapota) L. stem bark against Ehrlich ascites carcinoma (EAC) in Swiss albino mice.</p><p><b>METHODS</b>The in vivo antitumour activity of the ethyl acetate extract of stem bark of M. zapota L. (EASM) was evaluated at 50, 100 and 200 mg/kg bw against EAC using mean survival time. After administration of the extract of M. zapota, viable EAC cell count and body weight in the EAC tumour hosts were observed. The animal was also observed for improvement in the haematological parameters (e.g., heamoglobin content, red and white blood cells count and differential cell count) after EASM treatment.</p><p><b>RESULTS</b>Intraperitoneal administration of EASM reduced viable EAC cells, increased the survival time, and restored altered haematological parameters. Significant efficacy was observed for EASM at 100 mg/kg dose (P<0.05).</p><p><b>CONCLUSIONS</b>It can be concluded that the ethyl acetate extract of stem bark of M. zapota L. possesses significant antitumour activity.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Peso Corporal
/
Extratos Vegetais
/
Carcinoma de Ehrlich
/
Análise de Sobrevida
/
Sobrevivência Celular
/
Química
/
Resultado do Tratamento
/
Casca de Planta
/
Manilkara
/
Usos Terapêuticos
Limite:
Animais
Idioma:
Inglês
Revista:
Asian Pacific Journal of Tropical Biomedicine
Ano de publicação:
2011
Tipo de documento:
Artigo
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